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Title: Effects of Pomegranate Seed Oil on Glucose and Lipid Metabolism-Related Organs in Rats Fed an Obesogenic Diet
Authors: Miranda, Jonatan; Aguirre, Leixuri; Fernandez-Quintela, Alfredo; Guadalupe Martinez-Castano, M.; Ayo, Josune; Bilbao, Elisabette; Portillo, Maria P.; Teresa Macarulla, M.
Citation: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2013, 61, 5089-5096
Abstract: Studies conducted in mice have revealed positive effects of punicic acid (PUA). The aim of this study was to analyze the effects of PUA on fat accumulation and glycemic control in rats fed an obesogenic diet. Rats were randomly divided into two groups: control group and PUA group (diet supplemented with 0.5\% PUA). No changes were observed in adipose tissue weights. The glucose tolerance test showed that the glycemic value in the PUA group had decreased significantly at the final time (120 min) (-19.3\%), as had fructosamine levels (-11.1\%). However, homeostasis model assessment (HOMA-IR) showed that insulin resistance did not improve. No changes were observed in the liver, skeletal muscle composition, or peroxisome proliferator-activated receptors (PPARs) activation. Low levels (mg/g tissue) of PUA (0.04 +/- 0.01 in both tissues) and higher levels of cis-9,trans-11 conjugated linoleic acid (0.31 +/- 0.08 in liver, 0.52 +/- 0.11 in muscle) were found. PUA supplementation induced hypoplasia (-16.1\%) due to the antiproliferative effect on hepatocytes. In conclusion, dietary supplementation of 0.5\% PUA did not lead to decreased fat accumulation in adipose tissue, liver, or skeletal muscle, or to improved glycemic control. The hypoplasia induced in liver is a negative effect that should be considered before proposing PUA as a functional ingredient.
Keywords: punicic acid; liver; skeletal muscle; rat; glucose tolerance; CONJUGATED LINOLEIC-ACID; ACTIVATED RECEPTOR-ALPHA; PUNICIC ACID; CARNITINE PALMITOYLTRANSFERASE; INSULIN-RESISTANCE; BODY-COMPOSITION; GENE-EXPRESSION; LIVER; FAT; ISOMERS
Issue Date: 2013
Publisher: AMER CHEMICAL SOC
Type: Article
Language: English
DOI: 10.1021/jf305076v
URI: http://dspace.azti.es/handle/24689/537
ISSN: 0021-8561
E-ISSN: 1520-5118
Funder: Basque Country Government [IT-572-13]
Instituto de Salud Carlos III (PREDIMED)
Instituto de Salud Carlos III (CIBERObn)
University of the Basque Country (UPV/EHU) [ELDUNANOTEK UFI11/32]
Appears in Publication types:Artículos científicos



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