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dc.contributor.authorCabezas-Sanchez, Pablo
dc.contributor.authorRainieri, Sandra
dc.contributor.authorConlledo, Nadia and Barranco, Alejandro
dc.contributor.authorSanz-Landaluze, Jon
dc.contributor.authorCamara, Carmen and Luque-Garcia, Jose L.
dc.date.accessioned2020-10-07T14:24:37Z-
dc.date.available2020-10-07T14:24:37Z-
dc.date.issued2019
dc.identifierISI:000491634500047
dc.identifier.issn0045-6535
dc.identifier.urihttp://dspace.azti.es/handle/24689/927-
dc.description.abstractMercury still represents one of the most hazardous threats for the aquatic ecosystem due to its high toxicity, and the fact that it can be easily incorporated into the food chain by accumulation in fish as MeHg. On the other hand, selenium is a micronutrient that is part of different antioxidant enzymes that regulate the cellular redox state, and whose complex interaction with Hg has been extensively studied from a toxicological point of view. In order to evaluate the protective effect of Se(IV) co-administration against MeHg accumulation and toxicity, we have selected an in-vivo model at two developmental stages: zebrafish eleutheroembryos and adult fish. Embryos were exposed during 48 h to MeHg (5 or 25 mu g/l) and a concentration of Se (IV) representing a molar ratio close to one (2.5 or 12.5 mu g/l), while adult zebrafish were exposed during 72 h to either 25 mu g/l of MeHg alone or co-exposed with 12.5 mu g/l of Se (IV). A significant decrease in MeHg bioaccumulation factor was observed in eleutheroembryos co-exposed to Se(IV). A time-dependent accumulation of MeHg was observed in all the analyzed organs and tissues of adult fish, which was significantly reduced in the muscular tissue and the intestine by Se(IV) co-administration. However, such protection against MeHg bioaccumulation was not maintained in the brain and liver. The data derived from the gene expression analysis also demonstrated the protective effect of Se(IV) against MeHg-induced oxidative stress and the activation of different defense mechanisms by Se(IV) co-administration. (C) 2019 Elsevier Ltd. All rights reserved.
dc.language.isoEnglish
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.subjectMethylmercury
dc.subjectSelenite
dc.subjectBioaccumulation
dc.subjectGene expression
dc.subjectZebrafish
dc.subjectCENTRAL-NERVOUS-SYSTEM
dc.subjectOXIDATIVE STRESS
dc.subjectDEVELOPMENTAL TOXICITY
dc.subjectTHIOREDOXIN REDUCTASE
dc.subjectMERCURY ACCUMULATION
dc.subjectDIETARY SELENIUM
dc.subjectATLANTIC COD
dc.subjectRAT-BRAIN
dc.subjectGLUTATHIONE
dc.subjectLARVAE
dc.titleImpact of selenium co-administration on methylmercury exposed eleutheroembryos and adult zebrafish (Danio rerio): Changes in bioaccumulation and gene expression
dc.typeArticle
dc.identifier.journalCHEMOSPHERE
dc.format.volume236
dc.contributor.funderSpanish Ministry of Economy and Competitiveness [CTQ2017-85673-R, CTQ2017-83569-C2-1-R]
dc.contributor.funderEuropean Union Seventh Framework Programme (FP7/2007-2013) under the ECsafeSEAFOOD project [311820]
dc.identifier.e-issn1879-1298
dc.identifier.doi10.1016/j.chemosphere.2019.07.026
Appears in Publication types:Artículos científicos



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