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Title: The presence of the trans-10, cis-12 sequence does not have a body fat-lowering effect on jacaric acid, a conjugated linolenic acid isomer
Authors: Miranda, Jonatan; Fernandez-Quintela, Alfredo; Churruca, Itziar; Garcia-Marzo, Cristina; Dentin, Renaud; Puy Portillo, Maria; Ayo, Josune
Citation: FOOD CHEMISTRY, 2011, 129, 21-27
Abstract: The term conjugated linolenic acid (CLNA) includes multiple positional and geometric cis and trans isomers. The aim was to determine the potential effectiveness of jacaric acid, a CLNA isomer, on body fat reduction in rats fed a high-fat diet, and its ability to activate the peroxisome proliferator-activated receptors, PPAR alpha and PPAR gamma. CLNA did not modify adipose tissue weight nor did it modify the expression of lipoprotein lipase, acyl-CoA oxidase and carnitine palmitoyltransferase-Ia, but it did reduce that of PPAR alpha and PPAR gamma. Moreover, it was not able to activate these transcriptional factors. These results demonstrate that, despite the presence of the diene sequence trans-10, cis-12, in octadecatrienoic jacaric acid, it does not have body-fat-lowering properties, probably due to the first cis double bond placed in position 8. Furthermore, unlike other CLNA isomers, such as punicic and alpha-eleostearic acids, jacaric acid does not activate PPAR alpha and PPAR gamma. (C) 2011 Elsevier Ltd. All rights reserved.
Keywords: Jacaric acid; Body fat; Lipoprotein lipase; Acyl-CoA oxidase; Carnitine palmitoyltransferase-1a; PPAR alpha; PPAR gamma; Rat; PPAR-ALPHA; GLUCOSE-TOLERANCE; LIPID-METABOLISM; ADIPOSE-TISSUE; RATS; MECHANISMS; HEALTH; LIVER; CLA; EXPRESSION
Issue Date: 2011
Type: Article
Language: English
DOI: 10.1016/j.foodchem.2011.01.037
ISSN: 0308-8146
Funder: Ministerio de Educacion y Ciencia
Appears in Publication types:Artículos científicos

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