Por favor, use este identificador para citar o enlazar este ítem: http://dspace.azti.es/handle/24689/559
Ficheros en este ítem:
No hay ficheros asociados a este ítem.
Registro completo de metadatos
Campo DC Valor Lengua/Idioma
dc.contributor.authorSagardia, Iban
dc.contributor.authorRoa-Ureta, Ruben H.
dc.contributor.authorBald, Carlos
dc.date.accessioned2019-05-17T08:47:59Z-
dc.date.available2019-05-17T08:47:59Z-
dc.date.issued2013
dc.identifierISI:000313924900036
dc.identifier.citationFOOD CHEMISTRY, 2013, 136, 1370-1376
dc.identifier.issn0308-8146
dc.identifier.urihttp://dspace.azti.es/handle/24689/559-
dc.description.abstractA new quantitative structure activity relationship (QSAR) model is established for oligopeptides that inhibit angiotensin I-converting enzyme (ACE). Information concerning the C-terminal pentapeptide is considered to describe the peptide structure in the model. A database is constructed, with 263 ACE inhibitory peptides and 38 physicochemical descriptors, abstracted from the published literature. The model is generated through a generalised linear model, with a gamma distribution that yields a coefficient of determination of 94.4\%. The whole C-terminal pentapeptide information is a determinant for modelling the ACE inhibition activity of oligopeptides. Starting from the C-terminus, the C-1 position is the most relevant position in the model; this is followed by position C-4. In C-1, there is a preference for aliphatic and tiny residues. However, in the C-4 position, the model indicates a clear preference for bulky hydrophobic amino acids and for sulphur-containing amino acids. Due to its good predictive capability, this model could be used as a tool for identifying and prioritizing the potential ACE inhibitory peptides present in a complex matrix. (C) 2012 Elsevier Ltd. All rights reserved.
dc.language.isoeng
dc.publisherELSEVIER SCI LTD
dc.subjectQSAR
dc.subjectACE-inhibition
dc.subjectPeptides
dc.subjectGeneralised linear model
dc.subjectGamma distribution
dc.subjectAMINO-ACID DESCRIPTORS
dc.subjectSTRUCTURAL REQUIREMENTS
dc.subjectPEPTIDE QSAR
dc.subjectSTABILITY
dc.subjectPROTEINS
dc.subjectBINDING
dc.subjectCOMPLEX
dc.subjectDESIGN
dc.subjectSET
dc.titleA new QSAR model, for angiotensin I-converting enzyme inhibitory oligopeptides
dc.typeArticle
dc.identifier.journalFOOD CHEMISTRY
dc.format.page1370-1376
dc.format.volume136
dc.contributor.funderDepartment of Environment, Territorial Planning, Agriculture and Fisheries
dc.contributor.funderIndustry, Trade and Tourism Department of the Basque Government
dc.identifier.doi10.1016/j.foodchem.2012.09.092
Aparece en las tipos de publicación: Artículos científicos



Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.