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Título : Toxic effects of perfluorinated compounds at human cellular level and on a model vertebrate
Autor : Rainieri, Sandra; Conlledo, Nadia; Langerholc, Tomaz; Madorran, Eneko; Sala, Martin; Barranco, Alejandro
Citación : FOOD AND CHEMICAL TOXICOLOGY, 2017, 104, 14-25
Resumen : This work aims at deepening the understanding of the mode of action of some of the most prominent perfluorinated compounds (PFCs) by detecting in a realistic way their effects. To this end, after adjusting the exposure media taking into account the biological model employed and the physico-chemical properties of PFCs, we evaluated the toxic effects of PFOA, PFOS and PFNA in a human macrophage cell line (TLT cells) and in zebrafish embryos. We performed such evaluation on individual compounds and mixtures. Acute toxicity was greater for PFOS in zebrafish; however, it was greater for PFNA in TLT cells. PFNA was also the compound producing the greatest levels of oxidative stress, both in zebrafish and TLT cells. Additionally, in both biological systems, it showed a much stronger effect on mixtures in comparison to the others PFCs tested in this work. Mixture studies in zebrafish showed that acute toxicity depended on the concentration and that the mixture was far more toxic than the individual compounds. This study highlights the importance of studying PFCs in realistic conditions on various biological models. (C) 2017 Elsevier Ltd. All rights reserved.
Palabras clave : PFCs; Zebrafish; Oxidative stress; Toxicity; In vitro; In vivo; Mixtures; PERFLUOROOCTANE SULFONIC-ACID; PFOS-INDUCED APOPTOSIS; ZEBRAFISH EMBRYOS; PERFLUOROALKYL ACIDS; AMMONIUM PERFLUOROOCTANOATE; OXIDATIVE STRESS; GENE-EXPRESSION; DRINKING-WATER; EXPOSURE; FISH
Fecha de publicación : 2017
Editorial : PERGAMON-ELSEVIER SCIENCE LTD
Tipo de documento: Article
Idioma: Inglés
DOI: 10.1016/j.fct.2017.02.041
URI : http://dspace.azti.es/handle/24689/457
ISSN : 0278-6915
E-ISSN: 1873-6351
Patrocinador: European Union Seventh Framework Programme (FP7) under the ECsafeSEAFOOD project [311820]
Basque Country Government (Project Mixtox)
Aparece en las tipos de publicación: Artículos científicos



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