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Título : Molecular Differences Based on Erythrocyte Fatty Acid Profile to Personalize Dietary Strategies between Adults and Children with Obesity
Autor : Jauregibeitia, Iker; Portune, Kevin; Gaztambide, Sonia; Rica, Itxaso; Tueros, Itziar; Velasco, Olaia; Grau, Gema; Martin, Alicia; Castano, Luis; Larocca, Anna Vita; Di Nolfo, Federica and Ferreri, Carla; Arranz, Sara
Resumen : As the obesity epidemic continues to grow inexorably worldwide, the need to develop effective strategies to prevent and control obesity seems crucial. The use of molecular tools can be useful to characterize different obesity phenotypes to provide more precise nutritional recommendations. This study aimed to determine the fatty acid (FA) profile of red blood cell (RBC) membranes, together with the evaluation of their dietary intake and biochemical parameters, of children and adults with obesity. An observational study was carried out on 196 children (113 with normal weight and 83 with obesity) and 91 adults (30 with normal weight and 61 with obesity). Mature RBC membrane phospholipids were analyzed for FA composition by gas chromatography-mass spectrometry (GC-MS). Dietary habits were evaluated using validated food frequency questionnaires (FFQ). Children with obesity presented higher levels of omega-6 polyunsaturated FAs (mainly linoleic acid, p = 0.01) and lower values of omega-3 FAs (mainly DHA, p < 0.001) compared with adults. Regarding blood biochemical parameters, children with obesity presented lower levels of glucose, LDL cholesterol, and alanine aminotransferase compared with adults with obesity. These lipidomic differences could be considered to provide specific nutritional recommendations for different age groups, based on an adequate fat intake.
Palabras clave : lipid metabolism; mature erythrocyte; obesity; precision nutrition
Fecha de publicación : 2021
Editorial : MDPI
Tipo de documento: Article
Idioma: 
DOI: 10.3390/metabo11010043
URI : http://dspace.azti.es/handle/24689/1297
E-ISSN: 2218-1989
Patrocinador: Department of Environment: Territorial Planning: Agriculture and Fisheries of the Basque Country Government
Department of Health of the Basque Government [2017222033: OBESIA 2016-2019]
Centre for the Development of Industrial Technology (CDTI) of the Spanish Ministry of Science and Innovation [CER-20191010]
INC (INTERNATIONAL NUT AND DRIED FRUIT COUNCIL) [2016(II)-R01]
Fundacion Gangoiti
Aparece en las tipos de publicación: Artículos científicos



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