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Titulua: Potential of Erythrocyte Membrane Lipid Profile as a Novel Inflammatory Biomarker to Distinguish Metabolically Healthy Obesity in Children
Egilea: Jauregibeitia, Iker; Portune, Kevin; Rica, Itxaso; Tueros, Itziar; Velasco, Olaia; Grau, Gema; Castano, Luis; Di Nolfo, Federica; Ferreri, Carla; Arranz, Sara
Laburpena: Metabolically healthy obesity (MHO) has been described as BMI >= 30 kg/m(2), without metabolic disorders traditionally associated with obesity. Beyond this definition, a standardized criterion, for adults and children, has not been established yet to explain the absence of those metabolic disorders. In this context, biomarkers of inflammation have been proposed as suitable candidates to describe MHO. The use of mature red blood cell fatty acid (RBC FA) profile is here proposed since its membrane lipidome includes biomarkers of pro- and anti-inflammatory conditions with a strict relationship with metabolic and nutritional status. An observational study was carried out in 194 children (76 children with obesity and 118 children with normal weight) between 6 and 16 years old. RBC FAs were analyzed by gas chromatography-flame ionization detector (GC-FID). An unsupervised hierarchical clustering method was conducted on children with obesity, based on the RBC FA profile, to isolate the MHO cluster. The MHO cluster showed FA levels similar to children with normal weight, characterized by lower values of arachidonic acid, (total omega-6 FA, omega 6/omega 3 FA ratios and higher values for EPA, DHA, and total omega-3 FA) (for all of them p <= 0.01) compared to the rest of the children with obesity (obese cluster). The MHO cluster also presented lipid indexes for higher desaturase enzymatic activity and lower SFA/MUFA ratio compared to the obese cluster. These differences are relevant for the follow-up of patients, also in view of personalized protocols providing tailored nutritional recommendations for the essential fatty acid intakes.
Gako-hitzak: children; inflammation; lipidomics; mature erythrocyte membrane; metabolically healthy obesity; DIET QUALITY INDEX; MEDITERRANEAN DIET; FATTY-ACIDS; RISK; WEIGHT; FOOD; POPULATION; PREVALENCE; CHILDHOOD; FREQUENCY
Gordailuaren-data: 2021
Argitalpen: MDPI
Dokumentu mota: Article
Hizkuntza: 
DOI: 10.3390/jpm11050337
URI: http://dspace.azti.es/handle/24689/1256
E-ISSN: 2075-4426
Babeslea: Department of Environment: Territorial Planning: Agriculture and Fisheries of the Basque Country Government (EMOI project - ELKARTEK 2017)
Department of Environment: Territorial Planning: Agriculture and Fisheries of the Basque Country Government (EMOI project - Innovation Fund 2017)
Department of Health of the Basque Government [2017222033]
Centre for the Development of Industrial Technology (CDTI) of the Spanish Ministry of Science and Innovation under the grant agreement: TECNOMIFOOD project [CER-20191010]
INC (INTERNATIONAL NUT AND DRIED FRUIT COUNCIL) under the grant agreement OBINUT project [2016(II)-R01]
Fundacion Gangoiti 2018/19
Fundacion Gangoiti 2019/2020
Bildumetan azaltzen da:Artículos científicos



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