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dc.contributor.authorMolina-Fernandez, Noemi
dc.contributor.authorRainieri, Sandra
dc.contributor.authorMunoz-Olivas, Riansares and de Oro-Carretero, Paloma
dc.contributor.authorSanz-Landaluze, Jon
dc.date.accessioned2022-01-04T11:31:15Z-
dc.date.available2022-01-04T11:31:15Z-
dc.date.issued2021
dc.identifierWOS:000668427200001
dc.identifier.citationANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2021, 413, 5169-5179
dc.identifier.issn1618-2642
dc.identifier.urihttp://dspace.azti.es/handle/24689/1235-
dc.description.abstractAntidepressant drugs are widely used for the treatment of common mental or other psychiatric disorders such as depression, which affect about 121 million people worldwide. This widespread use has contributed to the input of these pharmaceuticals and their metabolites into the environment. The aim of this work was to develop an analytical method to quantify the most widely used antidepressant drugs, selective serotonin reuptake inhibitors (SSRI), and their main metabolites in the environment. For this, a new and reliable miniaturized extraction method based on dispersive SPE cleanup procedure for extraction of SSRI followed by derivatization with n-heptafluorobutyrylimidazole, and detection by GC-MS was developed. The methodology, including a first-order one-compartment model, was then applied to a bioconcentration study in zebrafish (Danio rerio) eleutheroembryos. The results showed low bioaccumulation of these compounds; however, a biotransformation evidence of the parent compounds into their metabolites was observed after 6 h of exposure. These results indicate the need to integrate metabolic transformation rates to fully model and understand the bioaccumulation patterns of SSRI and their metabolites. Graphical abstract
dc.language.isoEnglish
dc.publisherSPRINGER HEIDELBERG
dc.subjectBioconcentration
dc.subjectSSRIs and metabolites
dc.subjectGC-MS
dc.subjectZebrafish eleutheroembryos
dc.subjectPERSONAL CARE PRODUCTS
dc.subjectNEW-GENERATION ANTIDEPRESSANTS
dc.subjectSEROTONIN REUPTAKE INHIBITORS
dc.subjectPRESSURIZED LIQUID EXTRACTION
dc.subjectTANDEM MASS-SPECTROMETRY
dc.subjectSOLID-PHASE EXTRACTION
dc.subjectWHOLE-BLOOD
dc.subjectACTIVE METABOLITES
dc.subjectFISH-TISSUES
dc.subjectHUMAN PLASMA
dc.titleDevelopment of a method for assessing the accumulation and metabolization of antidepressant drugs in zebrafish (Danio rerio) eleutheroembryos
dc.typeArticle
dc.identifier.journalANALYTICAL AND BIOANALYTICAL CHEMISTRY
dc.format.page5169-5179
dc.format.volume413
dc.contributor.funderMinistry of Economy and Competitivity (Project SAFEFOOD) [CTQ2014-54801-C2-1-R]
dc.contributor.funderComunidad Autonoma of Madrid (Project AVANSECAL) [S2013/ABI-3028]
dc.contributor.funderUniversidad Complutense
dc.identifier.e-issn1618-2650
dc.identifier.doi10.1007/s00216-021-03486-2
Aparece en las tipos de publicación: Artículos científicos



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