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dc.contributor.authorMehrdana, Foojan
dc.contributor.authorLavilla, Maria
dc.contributor.authorKania, Per Walter
dc.contributor.authorPardo, Miguel Angel
dc.contributor.authorAudicana, Maria Teresa
dc.contributor.authorLongo, Natividad and Buchmann, Kurt
dc.date.accessioned2022-01-04T11:31:13Z-
dc.date.available2022-01-04T11:31:13Z-
dc.date.issued2021
dc.identifierWOS:000689998900001
dc.identifier.urihttp://dspace.azti.es/handle/24689/1220-
dc.description.abstractFish consumers may develop allergic reactions following the ingestion of fish products containing nematode larvae within the genus Anisakis. Sensitized patients may cross-react with proteins from insects, mites and mollusks, leading to allergic reactions even in the absence of the offending food. Potential cross-reactivity in Anisakis-allergic patients with larval proteins from other zoonotic parasites present in freshwater and sea fish should be investigated due to an increasing occurrence in certain fish stocks, particularly Contracaecum osculatum. In this work, we evaluated IgE-cross reactions by in vivo (skin prick tests with parasites extracts) and in vitro methods (IgE-ELISA and IgE-immunoblot). In vivo skin prick tests (SPT) proved the reactivity of Anisakis-sensitized patients when exposed to C. osculatum antigens. Sera from Anisakis-sensitized patients confirmed the reaction with somatic antigens (SA) and excretory/secretory proteins (ES) from C. osculatum. Only anecdotal responses were obtained from other freshwater worm parasites. Consequently, it is suggested that Anisakis-sensitized humans, especially patients with high levels of specific anti-Anisakis antibodies, may react to C. osculatum proteins, possibly due to IgE-mediated cross-reactivity.
dc.language.isoEnglish
dc.publisherMDPI
dc.subjectAnisakis simplex
dc.subjectContracaecum osculatum
dc.subjectallergens
dc.subjecthuman IgE
dc.subjectfreshwater parasites
dc.subjectcross-reactions
dc.subjectCOD GADUS-MORHUA
dc.subjectPSEUDOTERRANOVA-DECIPIENS
dc.subjectMAJOR ALLERGEN
dc.subjectREACTIVITY
dc.subjectFISH
dc.subjectSENSITIZATION
dc.subjectINFECTION
dc.subjectDIAGNOSIS
dc.subjectANTIGENS
dc.subjectLARVAE
dc.titleEvidence of IgE-Mediated Cross-Reactions between Anisakis simplex and Contracaecum osculatum Proteins
dc.typeArticle
dc.identifier.journalPATHOGENS
dc.format.volume10
dc.contributor.funderEuropean Union's Horizon 2020 research and innovation program [634429]
dc.identifier.e-issn2076-0817
dc.identifier.doi10.3390/pathogens10080950
Appears in Publication types:Artículos científicos



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