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Title: Omega 6 polyunsaturated fatty acids in red blood cell membrane are associated with xerostomia and taste loss in patients with breast cancer
Authors: Amezaga, J.; Ugartemendia, G.; Larraioz, A.; Bretana, N. and Iruretagoyena, A.; Camba, J.; Urruticoechea, A.; Ferreri, C. and Tueros, I
Abstract: Chemosensory and physical complaints are common disorders in cancer patients under chemotherapy treatments that may affect the food intake, leading to a decreased quality of life. Lipid metabolism is a major pathway of cancer proliferation, where erythrocyte membrane phospholipids and their fatty acid composition are promising tools for monitoring metabolic pathways. Relationship between lipid profile in erythrocyte membrane phospholipids and chemosensory alterations in 44 newly diagnosed patients with breast cancer was here investigated. Smell changes and xerostomia were the most common complaints, with xerostomia as the main influencing factor on the development of other taste disorders. Lipid profiles revealed significant negative correlation between diminution of linoleic acid levels and xerostomia as well as positive correlation between increased arachidonic acid and salty taste. The involvement of these polyunsaturated lipids suggests the importance of oxidative and nutritional conditions of cancer patients, which can affect the molecular status for taste signals.
Keywords: Dry mouth; Erythrocyte; Lipid profile; Chemosensory alterations; Linoleic acid; PUFA; CHEMOTHERAPY; MECHANISMS; DYSFUNCTION; PRODUCTS; SMELL
Issue Date: 2021
Publisher: ELSEVIER SCI LTD
Type: Article
Language: 
DOI: 10.1016/j.plefa.2021.102336
URI: http://dspace.azti.es/handle/24689/1203
ISSN: 0952-3278
E-ISSN: 1532-2823
Funder: Basque Country Government (Department of the Environment, Regional Planning, Agriculture and Fisheries)
AZTI
centre for Development of Industrial Technology (CDTI) of the Spanish Ministry of Science and Innovation [CER-20191010]
Appears in Publication types:Artículos científicos



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