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dc.contributor.authorFerreri, Carla
dc.contributor.authorSansone, Anna
dc.contributor.authorFerreri, Rosaria
dc.contributor.authorAmezaga, Javier
dc.contributor.authorTueros, Itziar
dc.date.accessioned2021-07-02T08:12:17Z-
dc.date.available2021-07-02T08:12:17Z-
dc.date.issued2020
dc.identifierISI:000578999000001
dc.identifier.urihttp://dspace.azti.es/handle/24689/1088-
dc.description.abstractFatty acids are closely involved in lipid synthesis and metabolism in cancer. Their amount and composition are dependent on dietary supply and tumor microenviroment. Research in this subject highlighted the crucial event of membrane formation, which is regulated by the fatty acids' molecular properties. The growing understanding of the pathways that create the fatty acid pool needed for cell replication is the result of lipidomics studies, also envisaging novel fatty acid biosynthesis and fatty acid-mediated signaling. Fatty acid-driven mechanisms and biological effects in cancer onset, growth and metastasis have been elucidated, recognizing the importance of polyunsaturated molecules and the balance between omega-6 and omega-3 families. Saturated and monounsaturated fatty acids are biomarkers in several types of cancer, and their characterization in cell membranes and exosomes is under development for diagnostic purposes. Desaturase enzymatic activity with unprecedentedde novopolyunsaturated fatty acid (PUFA) synthesis is considered the recent breakthrough in this scenario. Together with the link between obesity and cancer, fatty acids open interesting perspectives for biomarker discovery and nutritional strategies to control cancer, also in combination with therapies. All these subjects are described using an integrated approach taking into account biochemical, biological and analytical aspects, delineating innovations in cancer prevention, diagnostics and treatments.
dc.language.isoEnglish
dc.publisherMDPI
dc.subjectcancer cell membranes
dc.subjectfatty acid biosynthesis
dc.subjectessential fatty acids
dc.subjectdesaturase enzymes
dc.subjectfatty acid signaling
dc.subjectfatty acid biomarker
dc.subjectsapienic acid
dc.subjectsebaleic acid
dc.subjectmolecular nutrition
dc.subjectinflammation
dc.subjectBODY-MASS INDEX
dc.subjectMECHANISMS LINKING OBESITY
dc.subjectSTEAROYL-COA DESATURASE-1
dc.subjectCANCER CELL-PROLIFERATION
dc.subjectBREAST-CANCER
dc.subjectPOOLED ANALYSIS
dc.subjectADIPOSE-TISSUE
dc.subjectTUMOR PROGRESSION
dc.subjectANTHROPOMETRIC FACTORS
dc.subjectMOLECULAR-MECHANISMS
dc.titleFatty Acids and Membrane Lipidomics in Oncology: A Cross-Road of Nutritional, Signaling and Metabolic Pathways
dc.typeReview
dc.identifier.journalMETABOLITES
dc.format.volume10
dc.contributor.funderCentre for the Development of Industrial Technology (CDTI) of the Spanish Ministry of Science and Innovation under the grant agreement TECNOMIFOOD project [CER-20191010]
dc.identifier.e-issn2218-1989
dc.identifier.doi10.3390/metabo10090345
Appears in Publication types:Artículos científicos



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