Please use this identifier to cite or link to this item: http://dspace.azti.es/handle/24689/1088
Files in This Item:
There are no files associated with this item.
Title: Fatty Acids and Membrane Lipidomics in Oncology: A Cross-Road of Nutritional, Signaling and Metabolic Pathways
Authors: Ferreri, Carla; Sansone, Anna; Ferreri, Rosaria; Amezaga, Javier; Tueros, Itziar
Abstract: Fatty acids are closely involved in lipid synthesis and metabolism in cancer. Their amount and composition are dependent on dietary supply and tumor microenviroment. Research in this subject highlighted the crucial event of membrane formation, which is regulated by the fatty acids' molecular properties. The growing understanding of the pathways that create the fatty acid pool needed for cell replication is the result of lipidomics studies, also envisaging novel fatty acid biosynthesis and fatty acid-mediated signaling. Fatty acid-driven mechanisms and biological effects in cancer onset, growth and metastasis have been elucidated, recognizing the importance of polyunsaturated molecules and the balance between omega-6 and omega-3 families. Saturated and monounsaturated fatty acids are biomarkers in several types of cancer, and their characterization in cell membranes and exosomes is under development for diagnostic purposes. Desaturase enzymatic activity with unprecedentedde novopolyunsaturated fatty acid (PUFA) synthesis is considered the recent breakthrough in this scenario. Together with the link between obesity and cancer, fatty acids open interesting perspectives for biomarker discovery and nutritional strategies to control cancer, also in combination with therapies. All these subjects are described using an integrated approach taking into account biochemical, biological and analytical aspects, delineating innovations in cancer prevention, diagnostics and treatments.
Keywords: cancer cell membranes; fatty acid biosynthesis; essential fatty acids; desaturase enzymes; fatty acid signaling; fatty acid biomarker; sapienic acid; sebaleic acid; molecular nutrition; inflammation; BODY-MASS INDEX; MECHANISMS LINKING OBESITY; STEAROYL-COA DESATURASE-1; CANCER CELL-PROLIFERATION; BREAST-CANCER; POOLED ANALYSIS; ADIPOSE-TISSUE; TUMOR PROGRESSION; ANTHROPOMETRIC FACTORS; MOLECULAR-MECHANISMS
Issue Date: 2020
Publisher: MDPI
Type: Review
Language: 
DOI: 10.3390/metabo10090345
URI: http://dspace.azti.es/handle/24689/1088
E-ISSN: 2218-1989
Funder: Centre for the Development of Industrial Technology (CDTI) of the Spanish Ministry of Science and Innovation under the grant agreement TECNOMIFOOD project [CER-20191010]
Appears in Publication types:Artículos científicos



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.