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dc.contributor.authorAmezaga, Javier
dc.contributor.authorUgartemendia, Gurutze
dc.contributor.authorLarraioz, Aitziber and Bretana, Nerea
dc.contributor.authorIruretagoyena, Aizpea
dc.contributor.authorCamba, Joana and Urruticoechea, Ander
dc.contributor.authorFerreri, Carla
dc.contributor.authorTueros, Itziar
dc.date.accessioned2021-07-02T08:11:59Z-
dc.date.available2021-07-02T08:11:59Z-
dc.date.issued2020
dc.identifierISI:000593226300001
dc.identifier.urihttp://dspace.azti.es/handle/24689/1070-
dc.description.abstractRed blood cell (RBC) membrane can reflect fatty acid (FA) contribution from diet and biosynthesis. In cancer, membrane FAs are involved in tumorigenesis and invasiveness, and are indicated as biomarkers to monitor the disease evolution as well as potential targets for therapies and nutritional strategies. The present study provides RBC membrane FA profiles in recently diagnosed breast cancer patients before starting chemotherapy treatment. Patients and controls were recruited, and their dietary habits were collected. FA lipidomic analysis of mature erythrocyte membrane phospholipids in blood samples was performed. Data were adjusted to correct for the effects of diet, body mass index (BMI), and age, revealing that patients showed lower levels of saturated fatty acids (SFA) and higher levels of monounsaturated fatty acid, cis-vaccenic (25\%) than controls, with consequent differences in desaturase enzymatic index ( increment 9 desaturase, -13.1\%). In the case of polyunsaturated fatty acids (PUFA), patients had higher values of omega-6 FA (C18:2 (+11.1\%); C20:4 (+7.4\%)). RBC membrane lipidomic analysis in breast cancer revealed that omega-6 pathways are favored. These results suggest new potential targets for treatments and better nutritional guidelines.
dc.language.isoEnglish
dc.publisherMDPI
dc.subjectarachidonic acid
dc.subjectbreast cancer
dc.subjectlinoleic acid
dc.subjectmembrane lipidome
dc.subjectomega 6
dc.subjectred blood cell
dc.subjectSCD1
dc.subjectSTEAROYL-COA DESATURASE-1
dc.subjectMULTIDRUG-RESISTANCE
dc.subjectLIPID-METABOLISM
dc.subjectINSIGHTS
dc.subjectGROWTH
dc.titleAltered Levels of Desaturation and omega-6 Fatty Acids in Breast Cancer Patients' Red Blood Cell Membranes
dc.typeArticle
dc.identifier.journalMETABOLITES
dc.format.volume10
dc.contributor.funderBasque Country Government (Department of the Environment, Regional Planning, Agriculture and Fisheries)
dc.contributor.funderAZTI
dc.contributor.funderCentre for the Development of Industrial Technology (CDTI) of the Spanish Ministry of Science and Innovation under the grant agreement: TECNOMIFOOD project [CER-20191010]
dc.identifier.e-issn2218-1989
dc.identifier.doi10.3390/metabo10110469
Appears in Publication types:Artículos científicos



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