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dc.contributor.authorEreno Artabe, Amaia
dc.contributor.authorCunha-Silva, Hugo
dc.contributor.authorBarranco, Alejandro
dc.date.accessioned2021-07-02T08:11:58Z-
dc.date.available2021-07-02T08:11:58Z-
dc.date.issued2020
dc.identifierISI:000580355300022
dc.identifier.issn0278-6915
dc.identifier.urihttp://dspace.azti.es/handle/24689/1067-
dc.description.abstractHalogenated organic compounds are a particular group of contaminants consisting of a large number of substances, and of great concern due to their persistence in the environment, potential for bioaccumulation and toxicity. Some of these compounds have been classified as persistent organic pollutants (POPs) under The Stockholm Convention and many toxicity assessments have been conducted on them previously. In this work we provide an overview of enzymatic assays used in these studies to establish toxic effects and dose-response relationships. Studies in vivo and in vitro have been considered with a particular emphasis on the impact of halogenated compounds on the activity of relevant enzymes to the humans and the environment. Most information available in the literature focuses on chlorinated compounds, but brominated and fluorinated molecules are also the target of increasing numbers of studies. The enzymes identified can be classified as enzymes: i) the activities of which are affected by the presence of halogenated organic compounds, and those involved in their metabolisation/detoxification resulting in increased activities. In both cases the halogen substituent seems to have an important role in the effects observed. Finally, the use of these enzymes in biosensing tools for monitoring of halogenated compounds is described.
dc.language.isoEnglish
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.subjectEnzymes
dc.subjectHalogenated organic contaminants
dc.subjectToxicity
dc.subjectIn vitro
dc.subjectIn vivo
dc.subjectBiosensors
dc.subjectDISINFECTION BY-PRODUCTS
dc.subjectBROMINATED FLAME RETARDANTS
dc.subjectPERFLUOROOCTANE SULFONATE PFOS
dc.subjectPOLYBROMINATED DIPHENYL ETHERS
dc.subjectATMOSPHERIC PARTICULATE MATTER
dc.subjectWALLED CARBON NANOTUBES
dc.subjectMULLET MUGIL-CEPHALUS
dc.subjectRAY CONTRAST-MEDIA
dc.subjectPOLYCHLORINATED-BIPHENYLS
dc.subjectCHLORINATED HYDROCARBONS
dc.titleEnzymatic assays for the assessment of toxic effects of halogenated organic contaminants in water and food. A review
dc.typeReview
dc.identifier.journalFOOD AND CHEMICAL TOXICOLOGY
dc.format.volume145
dc.contributor.funderEuropean Union's Horizon 2020 research and innovation programme [773400]
dc.contributor.funderSpanish Ministry of Economy and Competitiveness (Project QUALSAFeFOOD) [CTQ2017-83569-C2-2-R]
dc.contributor.funderBasque GovernmentBasque Government
dc.identifier.e-issn1873-6351
dc.identifier.doi10.1016/j.fct.2020.111677
Aparece en las tipos de publicación: Artículos científicos



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