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Title: Enzymatic assays for the assessment of toxic effects of halogenated organic contaminants in water and food. A review
Authors: Ereno Artabe, Amaia; Cunha-Silva, Hugo; Barranco, Alejandro
Abstract: Halogenated organic compounds are a particular group of contaminants consisting of a large number of substances, and of great concern due to their persistence in the environment, potential for bioaccumulation and toxicity. Some of these compounds have been classified as persistent organic pollutants (POPs) under The Stockholm Convention and many toxicity assessments have been conducted on them previously. In this work we provide an overview of enzymatic assays used in these studies to establish toxic effects and dose-response relationships. Studies in vivo and in vitro have been considered with a particular emphasis on the impact of halogenated compounds on the activity of relevant enzymes to the humans and the environment. Most information available in the literature focuses on chlorinated compounds, but brominated and fluorinated molecules are also the target of increasing numbers of studies. The enzymes identified can be classified as enzymes: i) the activities of which are affected by the presence of halogenated organic compounds, and those involved in their metabolisation/detoxification resulting in increased activities. In both cases the halogen substituent seems to have an important role in the effects observed. Finally, the use of these enzymes in biosensing tools for monitoring of halogenated compounds is described.
Keywords: Enzymes; Halogenated organic contaminants; Toxicity; In vitro; In vivo; Biosensors; DISINFECTION BY-PRODUCTS; BROMINATED FLAME RETARDANTS; PERFLUOROOCTANE SULFONATE PFOS; POLYBROMINATED DIPHENYL ETHERS; ATMOSPHERIC PARTICULATE MATTER; WALLED CARBON NANOTUBES; MULLET MUGIL-CEPHALUS; RAY CONTRAST-MEDIA; POLYCHLORINATED-BIPHENYLS; CHLORINATED HYDROCARBONS
Issue Date: 2020
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Type: Review
Language: 
DOI: 10.1016/j.fct.2020.111677
URI: http://dspace.azti.es/handle/24689/1067
ISSN: 0278-6915
E-ISSN: 1873-6351
Funder: European Union's Horizon 2020 research and innovation programme [773400]
Spanish Ministry of Economy and Competitiveness (Project QUALSAFeFOOD) [CTQ2017-83569-C2-2-R]
Basque GovernmentBasque Government
Appears in Publication types:Artículos científicos



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